๐ LOR-2 Tablet
Generic Name: Lorazepam
Brand Name: LOR-2
Strength: 2 mg
Formulation: Oral Tablet
Manufacturer: Elikem Pharmaceuticals Pvt. Ltd.
Prescription Required: Yes
Therapeutic Class: Benzodiazepines
โ Indications & Uses
LOR-2 is primarily prescribed for the management of:
- Anxiety Disorders โ Provides short-term relief from symptoms such as excessive worry, tension, and irritability.
- Insomnia Associated with Anxiety โ Helps improve sleep quality by reducing nighttime anxiety.
- Preoperative Sedation โ Induces sedation and reduces pre-surgical anxiety.
- Adjunct in Seizure Management โ Occasionally used in acute seizure control (off-label use).
โ๏ธ Mechanism of Action
Lorazepam enhances the activity of gamma-aminobutyric acid (GABA), a key inhibitory neurotransmitter in the brain. This leads to decreased neuronal excitability, producing a calming, anxiolytic, sedative, and muscle-relaxant effect.
๐ Dosage & Administration
- Usual Adult Dose (Anxiety): 2โ3 mg per day in divided doses.
- Insomnia (due to anxiety): 2โ4 mg as a single bedtime dose.
- Elderly or Debilitated Patients: Start with 1โ2 mg/day in divided doses; adjust cautiously.
- Route: Oral โ with or without food.
- Duration: Short-term use recommended. Always taper off gradually under medical supervision.
Note: Dosing must be individualized based on severity and response.
โ ๏ธ Precautions & Warnings
- Risk of Dependence & Withdrawal: Not for long-term use. Taper dose under medical supervision.
- CNS Depression: May cause drowsiness, impaired judgment, or motor coordination. Avoid driving or using machinery.
- Alcohol Interaction: Do not consume alcohol; it increases sedative effects and may be dangerous.
- Use in Pregnancy/Lactation: Not recommended; may harm the fetus or newborn.
- Renal/Hepatic Impairment: Use with caution; dose adjustments may be necessary.
โ Side Effects
Common:
- Drowsiness
- Dizziness
- Weakness
- Confusion
- Fatigue
Serious (Seek immediate help):
- Respiratory depression
- Mood or behavioral changes
- Memory loss or blackouts
- Allergic reactions (rash, swelling, difficulty breathing)
๐ Drug Interactions
Potential interactions with:
- Other CNS depressants (e.g., opioids, antihistamines)
- Alcohol
- Antidepressants
- Antiepileptics
- Muscle relaxants
Always inform your healthcare provider of all medications you’re taking.
๐ฆ Storage Instructions
- Store at room temperature (15โ30ยฐC).
- Keep in a dry place, away from sunlight and moisture.
- Keep out of reach of children and pets.
๐ Summary
LOR-2 (Lorazepam 2 mg) by Elikem Pharmaceuticals is an effective short-term treatment for anxiety-related disorders, insomnia, and preoperative sedation. As a potent benzodiazepine, it should be used with care under proper medical supervision to avoid tolerance, dependence, or withdrawal complications.