Modafresh 200 – Product Information
General Overview
- Generic Name: Modafinil
- Brand Name: Modafresh 200
- Dosage Form: Oral tablet
- Strength: 200 mg
- Manufacturer: Various pharmaceutical companies in India
- Prescription Status: Prescription-only (Rx)
Indications
Modafresh 200 is used to promote wakefulness in individuals suffering from:
- Narcolepsy – A chronic sleep disorder causing excessive daytime sleepiness.
- Obstructive Sleep Apnea (OSA) – As an adjunct to CPAP therapy to reduce residual daytime sleepiness.
- Shift Work Sleep Disorder (SWSD) – For individuals with altered sleep patterns due to night shifts or irregular work hours.
Mechanism of Action
While the precise mechanism is not fully understood, modafinil is believed to work by increasing dopamine levels in the brain, enhancing wakefulness and alertness. It influences various neurotransmitter systems, including histamine, orexin, and norepinephrine pathways.
Dosage & Administration
- Narcolepsy & OSA: 200 mg once daily in the morning.
- SWSD: 200 mg approximately 1 hour before the start of the work shift.
- Special Populations:
- Hepatic impairment: Reduce dose to 100 mg daily.
- Elderly: Initiate at lower doses and monitor closely.
Always follow the prescribing physician’s dosage recommendations.
Warnings & Precautions
- Skin Reactions: Rare but serious conditions such as Stevens-Johnson Syndrome; discontinue use if rash occurs.
- Psychiatric Symptoms: Use with caution in patients with a history of depression, anxiety, mania, or psychosis.
- Cardiovascular Risk: Monitor blood pressure and heart rate; avoid in patients with known heart conditions.
- Pregnancy/Lactation: Not recommended unless clearly necessary; may pose a risk to the fetus.
Contraindications
- Known hypersensitivity to modafinil or any of the excipients.
Drug Interactions
- Hormonal Contraceptives: May reduce efficacy; use alternative contraception during and for 1 month after discontinuation.
- May interact with drugs metabolized by CYP enzymes (e.g., cyclosporine, warfarin, phenytoin).
Important Note
Modafresh 200 is a potent wakefulness-promoting agent and should only be used under medical supervision. Misuse or overuse may lead to dependence, side effects, or serious health issues.